IL-21 and IL-21 receptor
作者: Mary CollinsMatthew J. WhittersDeborah A. Young
作者单位: 1Inflammation, Wyeth Research
2Immunology/RA Musculoskeletal Sciences, Wyeth Research
刊名: Immunologic Research, 2003, Vol.28 (2), pp.131-140
来源数据库: Springer Journal
DOI: 10.1385/IR:28:2:131
关键词: IL-21IL-21RIL-21R-Deficient miceγ-CommonNK cellT cellB cellCytokine
英文摘要: Abstract(#br)Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R, that pairs with the γ-common cytokine receptor chain. The first experiments examining the biology of the IL-21 pathway reveal that it is a cytokine with effects on natural killer (NK) cells, T cells, and B cells. Mice deficient in the IL-21 R have also been made, and are being examined for the effects of the IL-21/IL-21R pathway in vivo. Here we summarize our current knowledge of this new cytokine pathway, and its role in innate and adaptive immunity.
全文获取路径: Springer  (合作)
影响因子:2.963 (2012)

  • receptor 接受体