Detection of lymphocyte subsets in peripheral blood of patients with drug eruption and its significance
药疹患者外周血淋巴细胞亚群的检测及其意义
作者: Tan FeiMo XiaohuiChen JiaZhang ChuguangHu TingtingWu FeiSong NingjingGu JunDepartment of Dermatology,Changhai Hospital Affiliated to the Second Military Medical UniversityCentral Laboratory,Shanghai Dermatology Hospital
刊名: International Journal of Laboratory Medicine, 2014(10), pp.1266-1267+1269
中文刊名: 国际检验医学杂志, 2014(10), pp.1266-1267+1269
来源数据库: CJFDTEMP_U
DOI: CNKI:SUN:GWSQ.0.2014-10-014
关键词: drug eruptionslymphocytes subsetsflow cytometryperipheral blood
中文关键词: 药疹淋巴细胞亚群流式细胞术外周血
英文摘要: Objective To analyze the changes of lymphocyte subsets in peripheral blood of patients with drug eruption. Methods 18newly diagnosed patients were served as the drug eruption group,and were subdivided into cephalosporin group(n= 9),penicillin group(n=5)and Chinese medicine group(n=4)according to different sensitizing drugs.20healthy people were taken as the control group.Flow cytometry were utilized to detect the percentages and absolute counts of T lymphocytes(CD3+,CD3+ CD4+and CD3+CD8+),B lymphocytes,natural killer cell(NK)and natural killer T lymphocytes(NKT)in their peripheral blood. Results Differences of percentages of T lymphocytes(CD3+,CD3+CD4+),B lymphocytes,NKT cells between the drug eruption group and the control group showed statistical significant(P<0.05).Difference of...
中文摘要: 目的分析药疹患者外周血淋巴细胞亚群的变化。方法将18例初诊药疹患者作为药疹组,根据致敏药物的不同将其分为头孢菌素组(n=9)、青霉素组(n=5)及中药组(n=4),将20例健康体检者作为对照组。应用流式细胞仪检测其外周血T淋巴细胞(CD3+、CD3+CD4+、CD3+CD8+)、B淋巴细胞、自然杀伤细胞(NK)和自然杀伤T淋巴细胞(NKT)所占百分比及其绝对计数。结果药疹组患者外周血T淋巴细胞(CD3+、CD3+CD4+)、B淋巴细胞和NKT细胞所占百分比与对照组的差异有统计学意义(P<0.05);药疹组患者CD3+CD8+淋巴细胞所占百分比与对照组的差异无统计学意义(P>0.05),而其T、B淋巴细胞亚群的绝对计数与对照组的差异有统计学意义(P<0.05)。结论药疹患者外周血CD3+、CD3+CD4+淋巴细胞所占百分比降低,NKT细胞所占百分比增高,这可能与患者免疫调节有关。
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