Long Non-coding RNA RP5-180C18.1 Expression and Its Prognostic Significance in Patients with Chronic Lymphocytic Leukemia
慢性淋巴细胞白血病患者长链非编码RNA RP5-180C18.1的表达及其预后评价作用
作者: SHAO YangHU YanpingLIU YongDepartment of Laboratory Medicine,Shengjing Hospital,China Medical UniversityDepartment of Hematology,Shengjing Hospital,China Medical University
刊名: Journal of China Medical University, 2018(04), pp.341-345
中文刊名: 中国医科大学学报, 2018(04), pp.341-345
来源数据库: CJFDTEMP_U
关键词: long non-coding RNAchronic lymphocytic leukemiaRNA RP5-180C18.1 expressionprognosis
中文关键词: 长链非编码RNA慢性淋巴细胞白血病RNA RP5-180C18.1表达预后
英文摘要: Objective To investigate the differential expression of RP5-180 C18.1 in chronic lymphocytic leukemia(CLL) and to explore its role in the diagnosis and prognosis of CLL. Methods Bone marrow samples of patients with CLL from Shengjing Hospital of China Medical University were collected and analyzed. The relative expression of RP5-180 C18.1 was detected by q PCR and analyzed statistically. Results The expression of RP5-180 C18.1 in patients with CLL was higher than in healthy controls(P = 0.013) and higher in patients with wild-type IGHV CLL(P = 0.023) than in those with the IGHV mutation. The expression was also higher in patients with ZAP70 up-regulation CLL(P = 0.002) than ZAP70 down-regulation CLL,although no difference was found in patients with CD38 up-regulation CLL compared with...
中文摘要: 目的 分析慢性淋巴细胞白血病(CLL)患者长链非编码RNA RP5-180C18.1的表达及其在CLL的诊断及预后中的作用。方法 收集本院就诊的CLL患者骨髓液并对患者进行随访,采用q PCR方法检测RP5-180C18.1的相对表达量。结果 与对照组比较,RP5-180C18.1在CLL患者高表达(P=0.013);与IGHV突变型CLL患者比较,RP5-180C18.1在IGHV野生型CLL患者中表达更高(P=0.023);与ZAP70低表达CLL患者比较,RP5-180C18.1在ZAP70高表达CLL患者中表达更高(P=0.002);然而,RP5-180C18.1在CD38高、低表达患者中无统计学差异(P=0.206);RP5-180C18.1高表达CLL患者预后更差,总生存期及无进展生存期更短(P分别为0.048、0.041)。结论 RP5-180C18.1表达可作为CLL诊断及预后分析指标。
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