Virtual Screening and Molecular Descriptor Analysis on Dietary Phytochemicals Against Heat Shock Protein 90 Enzyme
作者: Salam Pradeep SinghBolin Kumar Konwar
作者单位: 1Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur-784028, Assam, India.
刊名: Letters in Drug Design & Discovery, 2014, Vol.11 (1), pp.40-49
来源数据库: Bentham Journal
关键词: Hsp90cancerATPmolecular dockingmolecular descriptorsphytochemicalsHsp90CancerATPMolecular dockingMolecular descriptors
原始语种摘要: Cancer is a disease involving unregulated cell growth and grows uncontrollably forming malignant tumors, andinvades nearby parts of the body. There are over 200 different known cancers that afflict humans. The chances of survivingthis disease vary by the type and location. In 2007, cancer caused about 13% of all human deaths worldwide (7.9 million).In addition, various dietary phytochemicals having anticancer activity have been reported by certain in vivo and invitro studies. The present work focus on the molecular docking simulation studies of a set of 32 dietary phytochemicalspresent in fruits, vegetables, legumes, whole grains and nuts reported of having anticancer property against Heat shockprotein 90 (Hsp90). Hsp90 is an important promoter of oncogene addition and cancer cell...
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影响因子:0.845 (2012)

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关键词翻译
关键词翻译
  • docked 已停放的
  • anticancer 抗癌的
  • invitro 活体外
  • binding 装订
  • unregulated 修]不调整[UNREG
  • against 反对
  • molecular 分子的
  • having 满足条件
  • worldwide 世界的
  • survival 生存