Synthesis of Novel Spirooxindole Derivatives Using N-Phenylpiperazine as an Organocatalyst
作者: Seyedeh M. MahdaviAzizollah HabibiHadi DolatiSaber H. NasabSeyyed M. Shahcheragh
刊名: Letters in Organic Chemistry, 2016, Vol.13 (4), pp.316-321
来源数据库: Bentham Journal
关键词: 4H-pyranisatinn-phenylpiperazineorganocatalystspirooxindolethree-component reaction.
原始语种摘要: Background: The indole ring system and 4H-Pyran derivatives are significant componentsin many drugs and pharmaceutical agents and spirooxindole containing both indole and pyran ringshave been shown to possess a wide biological and pharmaceutical properties. Methods: We synthesized new derivatives of spirooxindole by a three-component reaction of isatinderivatives, malononitrile (or ethyl cyanoacetate) and beta-dicarbonyl compounds in the presence ofcatalytic amount of N-Phenylpiperazine (NPP) as an organocatalyst. Results: A series of novel derivatives of spirooxindole with potential biological properties were synthesized by a threecomponentreaction in the presence of catalytic amount of N-Phenylpiperazine (NPP) as an organocatalyst. NPP as an efficientcatalyst can be easily handled and...
全文获取路径: Bentham 
影响因子:0.667 (2012)

  • reaction 反酌
  • catalytic 催化的
  • derivatives 派生物
  • malononitrile 丙二腈
  • catalyst 催化剂
  • amount 总计
  • pyran 吡喃
  • attractive 有吸引力的
  • produce 制作
  • excellent 优秀的