Understanding the Evolutionary Relationship of M2 Channel Protein of Influenza A Virus and its Structural Variation and Drug Resistance
作者: Krishnasamy GopinathMuthusamy Karthikeyan
刊名: Current Bioinformatics, 2017, Vol.12 (3), pp.265-274
来源数据库: Bentham Journal
DOI: 10.2174/1574893611666161123153103
关键词: AmantadineEvolutionary lineageInfluenza A virusM2 channel proteinRimantadine.
原始语种摘要: Background: M2 channel protein of influenza A virus is one of the specific targets for theanti-influenza drugs amantadine and rimantadine. These drugs have lost their efficacy because of themutations in their drug interaction sites. Large-scale analysis of these influenza surface proteins maygive better elucidation for understanding the evolution of the proteins toward the drug resistantmechanism.
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影响因子:2.017 (2012)

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关键词翻译
关键词翻译
  • influenza 列性感冒
  • virus 病毒
  • protein 蛋白质
  • lineage 血统
  • understanding 理解
  • drugs 药品
  • rimantadine 金刚乙胺
  • channel 槽水道
  • their 他们的
  • evolution 进化