Pharmacological Study of the Effect of Licorice Alone and in Combination with Diclofenac Sodium on Hepatotoxicity-induced Experimentally in Rats.
作者: Hekma A. Abd El LatifSawsan S MahmoudGihan Farag AsaadMarwa El-Hussiny
刊名: Journal of Complementary and Integrative Medicine, 2011, Vol.8 (1)
来源数据库: Berkeley Electronic Journal
关键词: licoricediclofenac sodiumCCl4ischemia/reperfusionhepatotoxicity
英文摘要: The protective effect of licorice and diclofenac sodium in doses of 50 mg/kg bwt. and 5 mg/kg bwt. respectively against liver toxicity induced by CCl4 (1ml/kg bwt.) in olive oil [1:1 (v/v)] every other day for 8 weeks and by hepatic ischemia/reperfusion in adult male albino rats was studied. Different antioxidant and liver function parameters were reported to find the protective effect of both licorice and diclofenac sodium against hepatotoxicity. Results showed that licorice protected against CCl4-induced hepatotoxicity as well as ischemia/reperfusion-induced liver injury. On the other hand, diclofenac sodium caused deleterious effects, especially in presence of CCl4, where a high mortality rate was observed.
全文获取路径: BE Press  (合作)

  • induced 感应的
  • diclofenac 双氯芬酸
  • hepatotoxicity 肝毒性
  • against 反对
  • licorice 甘草
  • reperfusion 多次灌注液
  • albino 白化体
  • liver 
  • ischemia 局部贫血
  • sodium