Chapter 3 - Mass spectrometry for the quantification of drugs in biosamples
作者: Rafael LindenMarina Venzon AntunesJose Luiz Costa
作者单位: Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil
出版社: Elsevier Inc.,   2020
ISBN: 978-0-444-64066-6
来源数据库: Elsevier Book
DOI: 10.1016/B978-0-444-64066-6.00003-4
关键词: Biological specimensDried blood spotsGas chromatographyLiquid chromatographyMass spectrometryTherapeutic drug monitoring
原始语种摘要: This chapter presents an overview on the use of mass spectrometry assays for drug measurement in biosamples. Drug measurement in biological specimens, particularly in the context of therapeutic drug monitoring (TDM), requires the availability of robust and well-validated laboratory assays in order to render clinically useful information. Among several available analytical methods, mass spectrometry measurement systems, preferentially coupled to liquid chromatography, are currently the mainstay of assays for TDM. These methods usually present the required sensitivity for measurement of drug concentrations in small specimens, including dried blood spots, as well as the required specificity for clinical applications. There are numerous reports on the use of mass spectrometry coupled to both...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • spectrometry 光谱测定
  • coupled 耦合
  • chromatography 色层分离法
  • TDM Time Division Modulation
  • measurement 测量
  • monitoring 监视
  • fundamental 基本的
  • render 三层涂抹
  • mainstay 主桅前支索
  • liquid 液体