Chapter 9 - Therapeutic drug monitoring for antifungal triazoles: pharmacologic background and current status
作者: Andreas H. GrollSilke Gastine
作者单位: Center for Bone Marrow Transplantation and Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany
出版社: Elsevier Inc.,   2020
ISBN: 978-0-444-64066-6
来源数据库: Elsevier Book
DOI: 10.1016/B978-0-444-64066-6.00009-5
关键词: Antifungal agentsMycosesPharmacodynamicsPharmacokineticsPharmacologyTherapeutic drug monitoring
原始语种摘要: Invasive fungal infections are important causes of morbidity and mortality in critically ill and immunocompromised patients. Since these infections remain difficult to diagnose and can be rapidly fatal, appropriate antifungal therapy is key to successful prevention, management, and survival. The introduction of antifungal triazoles in the 1990s was a major breakthrough in antifungal chemotherapy and has revolutionized prevention and treatment over the ensuing decades: Fluconazole and itraconazole were the first viable alternatives to standard treatment with amphotericin B deoxycholate and assumed an important role in systemic antifungal prophylaxis in high-risk patient populations. A decade later, voriconazole became the first-line option for treatment of invasive aspergillosis, yielding...
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关键词翻译
关键词翻译
  • antifungal 抗真菌的
  • aspergillosis 曲霉病
  • amphotericin 两性霉素
  • mucormycosis 毛霉菌病
  • deoxycholate 脱氧胆酸
  • breakthrough 突破
  • monitoring 监视
  • prevention 妨碍
  • alternatives 代替案
  • treatment 处理