Chapter 10 - Therapeutic monitoring of antiepileptic drugs
作者: Cecilie Johannessen LandmarkSvein I. Johannessen
作者单位: Programme for Pharmacy, Oslo Metropolitan University, Oslo, Norway
出版社: Elsevier Inc.,   2020
ISBN: 978-0-444-64066-6
来源数据库: Elsevier Book
DOI: 10.1016/B978-0-444-64066-6.00010-1
关键词: Antiepileptic drugsPharmacokineticsSerum concentrationTherapeutic effectsAdverse effects
原始语种摘要: The aim of the present chapter is to discuss therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs), based on their pharmacokinetic properties in order to optimize the therapy to the individual patient. Due to the nature of epilepsy, it remains problematic to monitor AED treatment by direct observations of clinical response in the individual patient. A reasonably good correlation between serum drug concentration and clinical effect together with large interindividual differences in the rate of drug clearance are factors that together with the need to identify toxicity, test compliance, and elucidate possible clinical interactions would make TDM desirable. Few studies have been designed primarily to study the serum concentration–effect relationships. Several of the older drugs...
全文获取路径: Elsevier  (合作)

  • concentration 浓度
  • drugs 药品
  • antiepileptic 镇痫剂
  • systematic 有系统的
  • monitoring 监视
  • together 共同
  • serum 血清
  • effect 效应
  • established 确定
  • identify 视为同一