Chapter 12 - Assessing immunosuppressive drug concentrations in clinical practice
作者: Christoph Seger
作者单位: Labormedizinisches zentrum Dr Risch, Buchs, Switzerland
出版社: Elsevier Inc.,   2020
ISBN: 978-0-444-64066-6
来源数据库: Elsevier Book
DOI: 10.1016/B978-0-444-64066-6.00012-5
关键词: Cyclosporine AEverolimusImmunoassayImmunosuppressive drugLigand-binding assayMycophenolic acidSirolimusTacrolimusTDMTherapeutic drug monitoringTraceability
原始语种摘要: Therapeutic drug monitoring of immunosuppressive drugs, namely, cyclosporine A, tacrolimus, sirolimus, everolimus, and mycophenolic acid, is an accepted measurement service that strongly supports transplantation medicine worldwide. During the past twenty years, ligand-binding assays lost their predominance, and liquid chromatography with tandem mass spectrometry–based analysis platforms gained importance. This transformation step is now finished, with both solutions in routine use. However, comparability between these methodologies is limited since traceability of the measurements to higher-order reference materials and reference standards is currently incomplete—a frequent situation in drug monitoring and toxicology. The chapter will provide an overview of the development of this...
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关键词翻译
关键词翻译
  • reference 基准电压源
  • practice 实践
  • monitoring 监视
  • years 年代
  • traceability 示踪能力
  • standards 规程
  • over 在上方
  • importance 重要性
  • routine 程序
  • development 开发