Chapter 14 - Pharmacogenomics
作者: Zhuo ShaoLianna G. KyriakopoulouShinya Ito
作者单位: Department of Pediatrics, Division of Clinical and Metabolic Genetics, Hospital for Sick Children, Toronto, ON, Canada
出版社: Elsevier Inc.,   2020
ISBN: 978-0-444-64066-6
来源数据库: Elsevier Book
DOI: 10.1016/B978-0-444-64066-6.00014-9
关键词: Clinical decision supportGenetics and genomicsPersonalized medicinePharmacogeneticsPharmacogenomicsPrecision medicine
原始语种摘要: Pharmacogenomics (PGx) (used interchangeably with pharmacogenetics) evaluates a person's response to medications based on his or her genetic makeup. The field was established since 1950s and grew exponentially since the completion of Human Genome Project. Recently established PGx consortia have established clinically actionable practice guidelines to avoid gene variants–associated severe side effects and optimum dosing based on metabolic activity of the patient to a given drug. Currently, a number of ongoing studies are setting out to investigate the clinical validity and utility of PGx-based prescribing. They also evaluate implementation of PGx-based clinical decision support within electronic medical records. The cost-effectiveness of PGx with individual gene–drug pairs showed mixed...
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关键词翻译
关键词翻译
  • medicine 
  • dosing 配量
  • clinical 临床的
  • based 基于
  • established 确定
  • decision 决定
  • exponentially 按指数规律的
  • routine 程序
  • metabolic 新陈代谢的
  • actionable 能起诉的