The hepatic retinyl ester hydrolase activity is depressed at the onset of diabetes in BB rats
作者: Min ChenAlan B. R. ThomsonAndrew T. C. TsinTapan K. Basu
作者单位: 11 Department of Agricultural , Food & Nutritional Science , Division of Gastroenterology , University of Alberta , Edmonton , Canada
2 2 Department of Medicine , Division of Gastroenterology , University of Alberta , Edmonton , Canada
3 3 Division of Life Sciences , University of Texas at San Antonio , San Antonio , Texas , USA
刊名: British Journal of Nutrition, 2003, Vol.89 (2), pp.231-238
来源数据库: Cambridge University Press Journal
DOI: 10.1079/BJN2002753
原始语种摘要: Dietary vitamin A as retinyl ester is hydrolysed and re-esterified with long-chain fatty acids in the small intestine. The esterified vitamin A is subsequently stored in the liver, where it is hydrolysed to free retinol to be transported by carrier proteins to the target tissue. A decreased availability of retinol carrier proteins has been suggested to be responsible for affecting metabolic availability of vitamin A in type 1 diabetes. Using BB Wistar rats, the present study was undertaken to examine whether the presence of a hyperglycaemic state modifies retinyl ester hydrolase (REH) activity in the intestine and the liver. At the onset of diabetes, hepatic REH enzymatic activity was significantly (P<0·05) decreased. However, REH activity remained unaffected in the small intestine,...
全文获取路径: Cambridge U Press 
影响因子:3.302 (2012)

  • diabetes 糖尿病
  • retinyl 视黄基
  • ester 
  • palmitate 棕榈酸盐
  • depressed 扁平的
  • diabetic 糖尿病患者
  • intestine 
  • activity 活度
  • retinol 瑞叮醇
  • vitamin 维生素