Intestinal bile acid receptors are key regulators of glucose homeostasis
作者: Mohamed-Sami TrabelsiSophie LestavelBart StaelsXavier Collet
作者单位: 11 Institut National de la Santé et de la Recherche Médicale, U1048, Université Paul Sabatier, UPS, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC) , CHU Rangueil , 1 Avenue Jean Poulhès , BP84225, 31432 Toulouse , Cedex 4 , France
2 2 University Lille, Inserm, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes , Lille , France
刊名: Proceedings of the Nutrition Society, 2017, Vol.76 (3), pp.192-202
来源数据库: Cambridge University Press Journal
DOI: 10.1017/S0029665116002834
原始语种摘要: In addition to their well-known function as dietary lipid detergents, bile acids have emerged as important signalling molecules that regulate energy homeostasis. Recent studies have highlighted that disrupted bile acid metabolism is associated with metabolism disorders such as dyslipidaemia, intestinal chronic inflammatory diseases and obesity. In particular, type 2 diabetes (T2D) is associated with quantitative and qualitative modifications in bile acid metabolism. Bile acids bind and modulate the activity of transmembrane and nuclear receptors (NR). Among these receptors, the G-protein-coupled bile acid receptor 1 (TGR5) and the NR farnesoid X receptor (FXR) are implicated in the regulation of bile acid, lipid, glucose and energy homeostasis. The role of these receptors in the intestine...
全文获取路径: Cambridge U Press  (合作)
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来源刊物:
影响因子:3.674 (2012)

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关键词翻译
关键词翻译
  • homeostasis 体内平衡
  • glucose 葡萄糖
  • metabolism 代谢
  • intestine 
  • lipid 脂质
  • recent 近来的
  • associated 相关的
  • transmembrane 横跨膜的
  • modulate 
  • protein 蛋白质