Enhanced cell growth by nanoengineering zirconia to stimulate electrostatic fibronectin activation
作者: A I RubinsteinR F SabirianovF Namavar
作者单位: 1Department of Orthopaedic Surgery and Rehabilitation, UNMC, Omaha, NE 68198, USA
2Department of Physics, University of Nebraska, Omaha, NE 68182, USA
刊名: Nanotechnology, 2014, Vol.25 (6)
来源数据库: Institute of Physics Journal
DOI: 10.1088/0957-4484/25/6/065101
原始语种摘要: We address the enhanced bone growth on designed nanocrystalline zirconia implants as reported by in vivo experiments. In vitro experiments demonstrate that the activation of adhesive proteins on nanoengineered zirconia stimulates cell adhesion and growth as shown by confocal microscopy. Fibrillar fibronectin (FN) forms a matrix assembly on the nanostructured surface in the cell adhesion process. We discuss the importance of FN dimer activation due to its immobilization on the designed nanocrystalline ZrO2 implant fabricated by ion beam assisted deposition. The Monte-Carlo analysis indicates that FN activation on the surface can be promoted by selective electrostatic interactions between negatively charged ZrO2 surface patches and oppositely charged FN domains.
全文获取路径: IOP 
影响因子:3.842 (2012)

  • zirconia 氧化锆
  • electrostatic 静电的
  • growth 生长
  • oppositely 在相反的位置
  • activation 活化
  • microscopy 显微镜检查
  • surface 
  • deposition 沉积
  • immobilization 固定
  • assembly 组装