Multistructural biomimetic substrates for controlled cellular differentiation
作者: Anamaria I OrzaCarmen MihuOlga SoritauMircea DiudeaAdrian FloreaHorea MateiStefana BaliciThilak MudaligeGanesh K KanarpardyAlexandru S Biris
作者单位: 1Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, AR 72204, USA
2The Oncology Institute, Prof. Dr. I. Chiricuta, Republicii, No. 34–36, RO-400015, Cluj-Napoca, Romania
3Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Arany János, No. 11, RO-400015, Cluj-Napoca, Romania
4Department of Cell and Molecular Biology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, Luis Pasteur Street, 400349, Cluj-Napoca, Romania
5Arkansas Regional Laboratory, US Food and Drug Administration 3900 NCTR Road, Building 26, Jefferson, AR 72079, USA
刊名: Nanotechnology, 2014, Vol.25 (6)
来源数据库: Institute of Physics Journal
DOI: 10.1088/0957-4484/25/6/065102
原始语种摘要: Multidimensional scaffolds are considered to be ideal candidates for regenerative medicine and tissue engineering based on their potential to provide an excellent microenvironment and direct the fate of the cultured cells. More recently, the use of stem cells in medicine has opened a new technological opportunity for controlled tissue formation. However, the mechanism through which the substrate directs the differentiation of stem cells is still rather unclear. Data concerning its specific surface chemistry, topology, and its signaling ability need to be further understood and analyzed. In our study, atomic force microscopy was used to study the stiffness, roughness, and topology of the collagen (Coll) and metallized collagen (MC) substrates, proposed as an excellent substrate for...
全文获取路径: IOP 
影响因子:3.842 (2012)

  • metallized 化为金属
  • excellent 优秀的
  • cellular 细胞状的
  • capability 能力
  • substrate 基质
  • atomic 原子的
  • microscopy 显微镜检查
  • collagen 胶骨硬蛋白质
  • hybrid 杂种
  • regenerative 再生放大