pVEGF-loaded lipopolysaccharide-amine nanopolymersomes for therapeutic angiogenesis
作者: Wei TengZhonghui HuangYing ChenLichun WangQinmei WangHongzhang Huang
作者单位: 1Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology,Sun Yat-sen University, Guangdong 510600, People’s Republic of China
2Key Laboratory on Assisted Circulation, Ministry of Health, Cardiovascular Division, First Affiliated Hospital, Sun Yat-sen University, Guangdong 510080, People’s Republic of China
刊名: Nanotechnology, 2014, Vol.25 (6)
来源数据库: Institute of Physics Journal
DOI: 10.1088/0957-4484/25/6/065702
原始语种摘要: Therapeutic angiogenesis via gene delivery is promising for tissue survival and regeneration after injury or ischemia. A stable, safe and efficient gene vector is essential for successful angiogenesis. We have demonstrated that our newly developed lipopolysaccharide-amine nanopolymersomes (LNPs) have higher than 95% transfection efficiency when delivering pEGFP into mesenchymal stem cells (MSCs). To explore their clinical potential in therapeutic angiogenesis, in this study, we studied their toxicity, storage stability, protection ability to genes and efficacy to deliver therapeutic genes of pVEGF in MSCs and zebrafish. The results show that LNPs can condense pVEGF to form pVEGF-loaded nanopolymersomes (VNPs), and protect pVEGF against DNase digestion in 6 h. Both LNPs and VNPs have low...
全文获取路径: IOP 
影响因子:3.842 (2012)

  • therapeutic 治疗的
  • angiogenesis 血管生成
  • loaded 加负荷的
  • amine 
  • potential 
  • transfection 转染
  • protect 庇护
  • survival 生存
  • deliver 输送
  • untreated 未处理的