Comparative study of gelatin methacrylate hydrogels from different sources for biofabrication applications
作者: Zongjie WangZhenlin TianFredric MenardKeekyoung Kim
作者单位: 1School of Engineering, Faculty of Applied Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada
2Department of Chemistry, the Irving K. Barber School of Arts and Sciences, University of British Columbia, BC, V1V 1V7, Canada
刊名: Biofabrication, 2017, Vol.9 (4)
来源数据库: Institute of Physics Journal
DOI: 10.1088/1758-5090/aa83cf
原始语种摘要: Gelatin methacrylate (GelMA) hydrogel is a promising bioink for biofabrication applications due to its cost-effectiveness, ease of synthesis and biocompatibility to allow cell adhesion. However, the GelMA synthesized from a widely used porcine skin gelatin has a thermal gelation problem at room temperature. Here, we present thermally stable GelMA hydrogels at room temperature while maintaining the mechanical and biological properties comparable to porcine GelMA. The novel GelMA hydrogels were synthesized from fish skin and cold soluble gelatin. We systematically characterized the properties of the GelMA hydrogels from different sources. The properties include the degree of methacrylation, compressive Young’s modulus, mass swelling ratio, viscosity, and cell adhesion and proliferation in...
全文获取路径: IOP  (合作)
影响因子:3.705 (2012)

  • gelatin 
  • methacrylate 甲基丙烯酸酯
  • hydrogel 水凝胶
  • adhesion 粘附
  • soluble 可溶的
  • temperature 温度
  • droplet 液滴
  • applications 应用程序
  • porcine 猪的
  • thermal 热的