Cell-printed 3D liver-on-a-chip possessing a liver microenvironment and biliary system
作者: Hyungseok LeeSuhun ChaeJae Yun KimWonil HanJongmin KimYeongjin ChoiDong-Woo Cho
作者单位: 1Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Gyungbuk 790-784, Republic of Korea
2School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk, 37673, Republic of Korea
3Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784, Republic of Korea
刊名: Biofabrication, 2019, Vol.11 (2)
来源数据库: Institute of Physics Journal
DOI: 10.1088/1758-5090/aaf9fa
原始语种摘要: To overcome the drawbacks of in vitro liver testing during drug development, numerous liver-on-a-chip models have been developed. However, current liver-on-a-chip technologies are labor-intensive, lack extracellular matrix (ECM) essential for liver cells, and lack a biliary system essential for excreting bile acids, which contribute to intestinal digestion but are known to be toxic to hepatocytes. Therefore, fabrication methods for development of liver-on-a-chip models that overcome the above limitations are required. Cell-printing technology enables construction of complex 3D structures with multiple cell types and biomaterials. We used cell-printing to develop a 3D liver-on-a-chip with multiple cell types for co-culture of liver cells, liver decellularized ECM bioink for a 3D...
全文获取路径: IOP  (合作)
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影响因子:3.705 (2012)

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关键词翻译
关键词翻译
  • liver 
  • biliary 胆汁的
  • overcome 克服
  • developed 开发
  • essential 本质的
  • vascular 维管的
  • better 较好的
  • development 开发
  • printed 印刷
  • system