Different Lines of Rats Selectively-Bred for High Alcohol-Drinking Demonstrate Disparate Preferences for Nicotine Self-administration
作者: Amir H. RezvaniEdward D. LevinCorinne WellsSusan SladeMargaret MorrisonLindsey MarshallMatt MorrisJamie ConfinoCheyenne AllenbyLawrence Lumeng
作者单位: 1Department of Psychiatry and Behavioral Sciences
2Department of Medicine
刊名: Journal of Drug and Alcohol Research, 2016, Vol.5 , pp.1-9
来源数据库: Ashdin Publishing Journal
DOI: 10.4303/jdar/235972
关键词: AddictionAlcoholismAlcohol-preferring ratsNicotine self-administrationGenetics
原始语种摘要: Background. Alcohol and nicotine are commonly co-abused. The search for a common core of neural, behavioral, and genetic factors underlying addiction has been the goal of addiction research. Purpose. Genetic predisposition to high alcohol intake has been studied in rats by selectively breeding rats that have high preference for alcohol. The current experiments were conducted to determine if the level of intravenous nicotine administration for the various lines of alcohol-preferring rats differs from that for nonalcohol-preferring controls. Study design. Adult alcohol-naïve selectively-bred alcohol-preferring male rats from four lines (P, AA, HAD-1, sP) and their control nonalcohol-preferring rats (NP, ANA, LAD-1, sNP) were trained and given access to self-administer nicotine (0.03...
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  • nicotine 尼古丁
  • administration 管理
  • Alcohol 酒精
  • alcohol 
  • lines 线型
  • significantly 较大地
  • drinking 
  • intake 收气
  • determine 决心
  • conducted 有陪同的