Introduction: Liver fibrosis results from the perpetuation of the normal wound healing response resulting in an abnormal continuation of fibrogenesis (connective tissue production and deposition). Special care should be given for the recognition of the acute or chronic character of renal disease in liver cirrhosis patients. Hence; we planned the present study to assess the correlation of renal profile with the severity of disease in liver cirrhosis patients. Material and methods: The present study included evaluation of liver cirrhosis patients and finding of correlation of severity of disease with the renal profile. A total of 40 liver cirrhosis patients were included in the present study. Complete demographic and clinical details of all the patients were obtained. We carried out all the... haematological, hepatic and renal investigations in all the patients. Physical examination was done to look for any evidence of cardiac or renal involvement in each and every patient. Liver disease was staged according to Child-Pugh’s score. All the results of etiological profile, evidence of cirrhosis, hepato-renal syndrome, and renal investigation were tabulated and compared. All the results were analyzed by SPSS software. Results: A total of 40 liver cirrhosis patients were included in the present study. Out of 40, in 22 patients, alcohol was the etiologic factor. Renal profile of the liver cirrhosis patients was significantly associated with severity of disease in liver cirrhosis patients. Conclusion: Renal profile is altered significantly with increase in severity of disease in liver cirrhosis patients.