Introduction: Globally the incidence of type 2 DM is increasing due to various factors like a high level of insulin resistance, genetic predisposition, and environmental factors. Hyperglycemia characterizes type 2 DM due to insulin resistance or insulin deficiency with a group of metabolic abnormalities, which includes dyslipidemia, increase in macrovascular disease. So the present study aimed to assess the importance of fasting dyslipidemia concerning postprandial dyslipidemia, in the pathogenesis of atherosclerotic changes. Material and Methods: The present study conducted in the Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry, a tertiary health care center with an annual volume of 100,000 patients. The study approved by Institutional... Human Ethical Committee for the year 2015-2016. The investigation was initiated with 100 cases (type 2 DM patients) and 100 controls (Non-diabetic patients) equally distributed in both genders. As per procedure, informed consent taken from the patients in prescribed formats before their participation in the study. The statistical analysis done by using the Students unpaired‘t’-test. Results: The fasting and postprandial lipid profile significantly altered in individuals with type 2 diabetes when compared with controls. The postprandial lipid parameters significantly increased in the type 2 DM subjects as compared to the fasting lipid parameters, and the postprandial HDL level significantly decreased as compared to the fasting HDL level. Conclusion: Hence in the present study postprandial lipid profile significantly increased when compared with fasting lipid profile among type 2 DM patients. So we suggest to include the estimation of postprandial lipid profile, in addition to the fasting lipid profile to assess the risk for CVD among type 2 DM patients.