Introduction: Gallstones are becoming increasingly common; they are seen in all age groups, but the incidence increases with age. Gallstone disease produces diverse histopathological changes in gallbladder mucosa-namely, acute inflammation, chronic Inflammation, granulomatous inflammation, hyperplasia, cholesterolosis, dysplasia and carcinoma. Hence; we planned the present study to assess various responses of the gallbladder mucosa with the different characteristic of gall stones. Material and methods: The present study included evaluation of various changes occurring in gallbladder mucosa in patients undergoing cholecystectomy. The present study included histopathological examination of 50 gall stone patients who underwent cholecystectomy. All the sections were stained with H & E... staining and were analyzed by two independent pathologists. Morphological characteristic of the gallstones were characterized on the basis of criteria given previously in the literature. All the observations were recorded on excel sheet and were evaluated with SPSS software. Results: A total of 50 patients undergoing laparoscopic cholecystectomy were included in the present study. Out of 50 patients, in 80 percent of the patients, the stones were of mixed or combined type. Mean size of stones in patients with histopathologic diagnosis was 3.98 cm while in patients with hyperplasia and cholecystitis with metaplasia, the size of stone was found to be 1.5 and 0.85 cm respectively. Conclusion: Size of stone significantly correlates with the type of mucosal response in gallstone patients undergoing laparoscopic cholecystectomy.