Efficacy of Rituximab vs Tacrolimus in Pediatric Corticosteroid-Dependent Nephrotic Syndrome: A Randomized Clinical Trial
作者: Biswanath BasuAnja SanderBirendranath RoyStella PreusslerShilpita BaruaT. K. S. MahapatraFranz Schaefer
刊名: JAMA Pediatrics, 2018
来源数据库: American Medical Association
DOI: 10.1001/jamapediatrics.2018.1323
原始语种摘要: IMPORTANCE: Calcineurin inhibitors are an established first-line corticosteroid-sparing therapy for patients with corticosteroid-dependent nephrotic syndrome (CDNS), whereas B-lymphocyte–depleting therapy is mostly used as a rescue for calcineurin inhibitor–resistant cases. The positive efficacy and safety profile of rituximab raises the question of whether it could be used as a first-line alternative to calcineurin inhibitor therapy. OBJECTIVE: To compare the efficacy of rituximab and tacrolimus in maintaining relapse-free survival among children with CDNS. DESIGN, SETTING, AND PARTICIPANTS: A parallel-arm, open-label, randomized clinical trial was performed from May 8, 2015, to September 20, 2016, with 1-year follow-up in a single-center, tertiary care unit. A total of 176 consecutive...
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关键词翻译
关键词翻译
  • corticosteroid 皮质甾类
  • tacrolimus 血流谱
  • sparing 节约的
  • cumulative 累积的
  • prestudy 预先研究
  • survival 生存
  • children 子女
  • screened 筛过的
  • treat 处理
  • compared 肿瘤和正常组织细胞周期的比较