Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial
作者: Christine H. LeeTheodore SteinerElaine O. PetrofMarek SmiejaDiane RoscoeAnouf NematallahJ. Scott WeeseStephen CollinsPaul MoayyediMark CrowtherMark J. RopeleskiPadman JayaratneDavid HigginsYingfu LiNeil V. RauPeter T. Kim
作者单位: 1Hamilton Regional Laboratory Medicine Program, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada2Department of Medicine, McMaster University, Hamilton, Ontario, Canada3St Joseph's Healthcare, Hamilton, Ontario, C
2Division of Infectious Diseases and Immunity and Infection Research Centre, Vancouver Hospital and University of British Columbia, Vancouver, British Columbia, Canada
3Gastrointestinal Diseases Research Unit, Department of Medicine, Queen's University, Kingston, Ontario, Canada
4Division of Medical Microbiology and Infection Control, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada
5Division of Infectious Diseases and Immunity and Infection Research Centre
刊名: JAMA, 2016, Vol.315 (2), pp.142-149
来源数据库: American Medical Association
DOI: 10.1001/jama.2015.18098
原始语种摘要: IMPORTANCE: Clostridium difficile infection (CDI) is a major burden in health care and community settings. CDI recurrence is of particular concern because of limited treatment options and associated clinical and infection control issues. Fecal microbiota transplantation (FMT) is a promising, but not readily available, intervention. OBJECTIVE: To determine whether frozen-and-thawed (frozen, experimental) FMT is noninferior to fresh (standard) FMT in terms of clinical efficacy among patients with recurrent or refractory CDI and to assess the safety of both types of FMT. DESIGN, SETTING, AND PARTICIPANTS: Randomized, double-blind, noninferiority trial enrolling 232 adults with recurrent or refractory CDI, conducted between July 2012 and September 2014 at 6 academic medical centers in Canada....
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关键词翻译
关键词翻译
  • frozen 冷冻的
  • population 母体
  • difference 区别
  • fresh 新鲜的
  • whether 是否
  • CDI Collector Diffusion Isolation
  • determine 决心
  • conducted 有陪同的
  • included 内藏的
  • proportion 比例