Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency †
作者: Yating ZhengChao LiuYan LiHaijuan JiangPeixin YangJing TangYing XuHan WangYulong He
刊名: Biology of Reproduction, 2019, Vol.100 (4), pp.1066-1072
来源数据库: BioOne Complete
DOI: 10.1093/biolre/ioy245
关键词: PER1PER2Ovarian follicleOvarian insufficiencyKnockout mouse
原始语种摘要: The mechanism underlying premature ovarian insufficiency remains incompletely understood. Here we report that mice with Per1m/m; Per2m/m double mutations display a decrease in female fertility starting approximately at 20 weeks old, with significantly less pups born from 32 weeks old onwards. Histological analysis revealed that a significant reduction of ovarian follicles was observed in the Per1/Per2 mutants compared with the littermate controls examined at 26 and 52 weeks old, while the difference was not statistically significant between the two groups at 3 and 8 weeks old. We further showed that vascular development including the ovarian follicle associated vascular growth appeared normal in the Per1/Per2 mutant mice, although clock genes were reported to regulate angiogenesis in...
影响因子:4.027 (2012)

  • ovarian 卵巢的
  • insufficiency 机能不全
  • circadian 昼夜节律
  • rhythm 韵律
  • regulator 第器
  • follicle 滤泡
  • significantly 较大地
  • underlying 下伏的
  • starting 起动
  • premature 早熟的