Longitudinal ambulatory measurements of gait abnormality in dystrophin-deficient dogs
作者: Inès BarthélémyEric BarreyPablo AguilarAne UriarteMatthias Le ChevoirJean-Laurent ThibaudThomas VoitStéphane BlotJean-Yves Hogrel
来源数据库: SJBM BioMed 文献
DOI: 10.1186/1471-2474-12-75
关键词: TOTAL POWERDUCHENNE MUSCULAR DYSTROPHYGAIT ANALYSISSTRIDE LENGTHDUCHENNE MUSCULAR DYSTROPHY
原始语种摘要: This study aimed to measure the gait abnormalities in GRMD (Golden retriever muscular dystrophy) dogs during growth and disease progression using an ambulatory gait analyzer (3D-accelerometers) as a possible tool to assess the effects of a therapeutic intervention. Six healthy and twelve GRMD dogs were evaluated twice monthly, from the age of two to nine months. The evolution of each gait variable previously shown to be modified in control and dystrophin-deficient adults was assessed using two-ways variance analysis (age, clinical status) with repeated measurements. A principal component analysis (PCA) was applied to perfect multivariate data interpretation. Speed, stride length, total power and force significantly already decreased (p < 0.01) at the age of 2 months. The other gait...
全文获取路径: BMC 
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影响因子:1.875 (2012)

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关键词翻译
关键词翻译
  • ambulatory 步行的
  • dystrophin 抗肌萎缩蛋白
  • abnormality 反常
  • deficient 缺乏