Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF)
作者: Shaney L. BarrattThomas BlytheKhadija OurradiCaroline JarrettGavin I. WelshDavid O. BatesAnn B. Millar
来源数据库: SJBM BioMed 文献
DOI: 10.1186/s12931-017-0711-x
关键词: INTERSTITIAL LUNG DISEASEVASCULAR ENDOTHELIAL GROWTH FACTORHYPOXIAIDIOPATHIC PULMONARY FIBROSIS
原始语种摘要: Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Axxxa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Axxxa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Axxxa isoforms as drivers of fibrogenesis.
全文获取路径: BMC 
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影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • hypoxia 氧过少
  • IPF Information Processing Facility
  • hyperoxia 氧过多
  • expression 表示
  • differential 差动的