A randomised, double-blind, placebo-controlled trial of minocycline and/or omega-3 fatty acids added to treatment as usual for at-risk mental states (NAYAB): study protocol
作者: Inti QurashiImran B. ChaudhryAmeer B. KhosoSana FarooqueSteve LaneMohammad Omair HusainSimon ChuJane SarginsonMunir HamaraniHaider A. NaqviBushra RazzaqueFareed A. MinhasAlison R. YungJ. F. W. DeakinNusrat Husain
来源数据库: SJBM BioMed 文献
DOI: 10.1186/s13063-017-2275-y
关键词: MINOCYCLINEOMEGA-3 FATTY ACIDSPUFAAT-RISK MENTAL STATE (ARMS)ULTRA-HIGH RISK (UHR) SCHIZOPHRENIAGLOBAL MENTAL HEALTH
原始语种摘要: The at-risk mental state (ARMS) describes individuals at high risk of developing schizophrenia or psychosis. The use of antipsychotics in this population is not supported, because most individuals with ARMS are unlikely to develop psychosis. Anti-inflammatory treatments and polyunsaturated fatty acids (PUFAs) may have some beneficial effects in the treatment of ARMS. There have been no controlled clinical trials in which researchers have investigated the use of minocycline for ARMS and no trials involving PUFAs in combination with other proposed treatments. There is a need to find effective, tolerable and inexpensive interventions for individuals with ARMS that are available in high-, low- and middle-income countries. A 6-month intervention study of minocycline and/or omega-3 fatty acids...
全文获取路径: BMC 
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影响因子:2.206 (2012)

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关键词翻译
关键词翻译
  • minocycline 二甲胺四环素
  • omega 奥米加
  • controlled 受控
  • usual 通常的
  • placebo 无效对照药
  • fatty 脂肪的
  • trial 试验
  • treatment 处理
  • mental 精神的
  • added 增添的