VEGF isoforms have differential effects on permeability of human pulmonary microvascular endothelial cells
作者: Khadija OurradiThomas BlytheCaroline JarrettShaney L. BarrattGavin I. WelshAnn B. Millar
来源数据库: SJBM BioMed 文献
DOI: 10.1186/s12931-017-0602-1
关键词: VASCULAR PERMEABILITYVASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)CELL SIGNALLING
原始语种摘要: Alternative splicing of Vascular endothelial growth factor-A mRNA transcripts (commonly referred as VEGF) leads to the generation of functionally differing isoforms, the relative amounts of which have potentially significant physiological outcomes in conditions such as acute respiratory distress syndrome (ARDS). The effect of such isoforms on pulmonary vascular permeability is unknown. We hypothesised that VEGF165a and VEGF165b isoforms would have differing effects on pulmonary vascular permeability caused by differential activation of intercellular signal transduction pathways. To test this hypothesis we investigated the physiological effect of VEGF165a and VEGF165b on Human Pulmonary Microvascular Endothelial Cell (HPMEC) permeability using three different methods: trans-endothelial...
全文获取路径: BMC 
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影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • pulmonary 肺的
  • differential 差动的
  • permeability 磁导率
  • cells 麻风细胞
  • microvascular 微脉管(直径小于0.3 毫米的微血管)的
  • human 人的
  • endothelial 内皮的
  • effects 海员自身物品