Polycation/DNA complexes for in vivo gene delivery
作者: Ralf KircheisErnst Wagner
刊名: Gene Therapy and Regulation, 2000, Vol.1 (1), pp.95 -114
来源数据库: Brill期刊
DOI: 10.1163/156855800744557
原始语种摘要: A major aim of in vivo gene transfer strategies is the efficient and specific delivery of therapeutic genes into the desired target tissues. Non-viral vectors, based on naked plasmid DNA or DNA complexes with cationic lipids or polycationic polymers, are attractive gene delivery vehicles because of their ease of manipulation, stability, low cost, safety, and their high flexibility concerning the size of the delivered transgene. A variety of non-viral vectors effective for gene transfer in cell culture have been developed. However, efficient and target specific in vivo gene delivery remains a major challenge. Compared to cell culture application, in vivo gene delivery faces a variety of additional obstacles including anatomical size constraints, and an environment of interactions with...
全文获取路径: Brill Press 
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关键词翻译
关键词翻译
  • 转染 联合企业
  • delivery 移交
  • target 目标
  • unspecific 非特定的
  • complexes 联合企业
  • transfection 联合企业
  • polycation 聚阳离子
  • DNA Deoxyribonucleic Acid
  • anatomical 解剖的
  • transgene 输异基因
  • naked 裸的