Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides
作者: Catherine H. WuCherie M. WaltonGeorge Y. Wu
刊名: Gene Therapy and Regulation, 2000, Vol.1 (2), pp.193 -205
来源数据库: Brill期刊
DOI: 10.1163/156855800744610
原始语种摘要: In hepatic fibrosis, the connective tissue biomatrix of the liver changes from the normal matrix, rich in basement membrane collagens, to a matrix enriched in interstitial fibrillar collagens. Type I collagen is the predominant component of thick fibrous bands found in matrix in advanced fibrosis. The aim of the current research was to determine whether a therapeutic approach could be developed that would specifically target collagen-producing cells to reduce the synthesis and accumulation of type I collagen. Antisense DNA oligonucleotides directed against specific sequences within α1(I) and α2(I) mRNA of type I procollagen were complexed to a cell-specific carrier, and screened for their effectiveness in reducing α1(I) and α2(I) mRNA levels. Two antisense DNA oligonucleotides delivered...
全文获取路径: Brill Press 
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关键词翻译
关键词翻译
  • procollagen 酸溶胶原蛋白
  • synthesis 合成
  • fibrosis 纤维化
  • mRNA m核糖核酸
  • inhibiting 抑制
  • cells 麻风细胞
  • interstitial 间隙原子
  • reducing 还原
  • inhibition 抑制
  • connective 连索