Antiangiogenic gene therapy
作者: Yihai Cao
刊名: Gene Therapy and Regulation, 2000, Vol.1 (2), pp.123 -139
来源数据库: Brill期刊
DOI: 10.1163/156855800744575
原始语种摘要: A number of potent endogenous inhibitors targeting the tumor vasculature have recently been identified in tumor-bearing animals. Some of these angiogenesis inhibitors, including angiostatin, endostatin, and serpin antithrombin, seem to act specifically on the proliferating endothelial cells in the newly formed blood vessels. The discovery of these specific endothelial inhibitors not only increases our understanding of the functions of these molecules in the regulation of physiological and pathological angiogenesis, but also provides an important therapeutic strategy for cancer treatment. Several studies have demonstrated that antiangiogenic protein therapy with these inhibitors significantly suppresses the growth of a variety of tumors in mice. However, the dosages of these endogenous...
全文获取路径: Brill Press 

  • potent 强大的
  • therapy 治疗
  • angiogenesis 血管生成
  • therapeutic 治疗的
  • endogenous 内成的
  • targeting 导向目标
  • protein 蛋白质
  • alternative 可选择的
  • pathological 病理学的
  • clinic 诊疗所