Liver-selective nucleic acid targeting using the asialoglycoprotein receptor
作者: Toshiko FukumaGeorge Y. WuCatherine H. Wu
刊名: Gene Therapy and Regulation, 2000, Vol.1 (1), pp.79 -93
来源数据库: Brill期刊
DOI: 10.1163/156855800744548
原始语种摘要: Gene transfer to the liver by receptor-mediated endocytosis represents a promising method for therapeutic intervention of genetic disorders and acquired diseases affecting the liver. Based on the observation that asialoglycoprotein receptors are abundantly expressed on the surface of human hepatocytes in vivo, gene delivery and expression by DNA-ligand complexes targeted to liver have been developed in several different experimental models. This review will cover general aspects related to targeting to the liver via the asialoglycoprotein receptor, and the relationship between gene expression, persistence, the structure and size of DNA complexes, as well as the current strategies aimed to improve the overall efficiency of receptor-mediated gene therapy.
全文获取路径: Brill Press 

  • targeting 导向目标
  • receptor 接受体
  • expression 表示
  • several 各自
  • liver 
  • genetic 遗传的
  • targeted 对准目标的
  • expressed 榨出的
  • observation 观测
  • complexes 联合企业