MLV-derived retroviral pseudotype vectors
作者: Jörn StitzChristian J. BuchholzKlaus Cichutek
刊名: Gene Therapy and Regulation, 2000, Vol.1 (2), pp.177 -192
来源数据库: Brill期刊
DOI: 10.1163/156855800744601
原始语种摘要: One of the strategies used to alter the tropism of retroviral vectors involves the substitution of their envelope glycoproteins with those of other viruses. This results in the generation of pseudotype vector particles exhibiting properties that may be advantageous for gene transfer into certain human cells. Moreover, when the envelope glycoproteins from simian and human immunodeficiency viruses were used to pseudotype Murine Leukemia Virus (MLV), the resulting vectors mediated selective gene transfer into defined human cell types. Enhanced transduction efficacy and cell targeting via retroviral pseudotype vectors may be important prerequisites for future gene therapy applications.
全文获取路径: Brill Press 

  • 世代 重要的
  • pseudotype 假模标本
  • envelope 包络层
  • targeting 导向目标
  • important 重要的
  • generation 重要的
  • advantageous 优越
  • substitution 同位素置换
  • human 人的
  • those 
  • simian