The Deficiency of Nuclear Proteins GATA6 and Lamin A/C as Prognostic Factor for Cervical Neoplasia
作者: D. Capo-chichi CalliniceAguida BlancheQi Cai KathyOffrin GeorgesK Agossou VidéhouénouSanni AmbaliouXu Xiang-Xi
作者单位: 1Institute of Biomedical Sciences and Applications (ISBA), Division of Molecular Biomarkers in Cancer and Nutrition (BMCN), Unit of Biochemistry and Molecular Biology (UBBM), Faculty of Sciences and Technologies (FAST), University Abomey-Calavi (UAC), Cotonou, BENIN
2Fox Chase Cancer Center, Philadelphia, PA 19111, USA
3Hospital Mènontin, BP 160, Cotonou, BENIN
4National University Hospital (CNHU), Cotonou, BENIN
5Sylvester Cancer Center/ Miller School of Medicine, Department of Cell Biology, University of Miami, FL 33136, USA
刊名: American Journal of Cancer Prevention, 2015, Vol.3 (6), pp.109-116
来源数据库: Science and Education Publishing
DOI: 10.12691/ajcp-3-6-2
原始语种摘要: BACKGROUND: Cervical cancer is a deadly disease for women worldwide and could be prevented if early molecular screening was performed ahead of cytology. In most neoplastic lesions the expression of nuclear proteins GATA6 and/or lamin A/C is deficient. OBJECTIVE: To analyze GATA6 and lamin A/C in archived cervical epithelial tissues and in cells derived from cervical uterine smears (CUS). METHODS: Immunofluorescence was used to analyze GATA6 and lamin A/C in epithelial cell lines. Immunohistochemistry was used to analyze GATA6 and lamin A/C expression in normal and neoplastic archived cervical tissues. Immunoblotting was used to analyze GATA6 and lamin A/C in cells of CUS obtained freshly from 40 selected women (age 20-45 years) who were attending routine gynecological checkup in Hospital...
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  • cervical 颈的
  • lamin 核纤层蛋白
  • uterine 子宫的
  • gynecological 妇科学的
  • cervix 
  • neoplastic 瘤的
  • cytology 细胞学
  • epithelial 上皮的
  • deadly 致死
  • worldwide 世界的