Dynamism of Ribosomal Protein RPL28 as Biomarker for Monitoring Epigenetic-initiated-breast-cancer Therapy
作者: Houngu¨¨ SaraAguida BlancheD. Capo-chichi Callinice
作者单位: 1Department of Biochemistry and Cell Biology, Division of Molecular Biology in Cancer and Nutrition (BMCN), Faculty of Sciences and Technics (FAST), University of Abomey Calavi (UAC), Abomey Calavi, BENIN
刊名: American Journal of Biomedical Research, 2019, Vol.7 (1), pp.21-26
来源数据库: Science and Education Publishing
DOI: 10.12691/ajbr-7-1-5
原始语种摘要: Background: Many oncology biomarkers were reported for breast cancer diagnosis and targeted therapy. Most biomarkers were hormonal receptors, but few studies integrated GATA transcription factors, nuclear envelop protein lamin A and ribosomal proteins, all of which were disrupted in cancer to facilitate cell proliferation, migration and metastasis. The overexpression of GATA6 in breast cancer cells is involved in epithelial-mesenchymal transition (EMT) while the overexpression of ribosomal large subunit (60S) protein RPL28 is involved in protein synthesis and cell proliferation. The objective of this study is to investigate in breast cancer cell line MCF7 the expression profile of GATA6 and RPL28 as biomarkers to evaluate the efficiency of breast cancer therapy with histone deacetylase...
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  • breast 胸部
  • expression 表示
  • protein 蛋白质
  • evaluate 求...的值
  • fluorescent 萤光的
  • cancer 癌症
  • lamin 核纤层蛋白
  • transfection 转染
  • involved 涉及
  • investigate