Presence of Lamin A is Required for GATA3 and ERα Downregulation by Histone Deacetylase Inhibitor in Breast Cancer Cells
作者: D. Capo-chichi CalliniceGnangnon FreddyMekpossi CharlesHoungue SaraXu Xiang-XiOlory-Togbé Jean-Leon
作者单位: 1Institute of Biomedical Sciences and Applications (ISBA), Division of Molecular Biomarkers in Cancer and Nutrition (BMCN), Department of Biochemistry and Cell biology, Faculty of Sciences and Technology (FAST), University of Abomey-Calavi (UAC)
2Visceral Surgery, National University Hospital (CNHU-HKM), School of Medicine, University of Abomey-Calavi (UAC)
3Sylvester Comprehensive Cancer Center, Miller Medical School, University of Miami
4Visceral Surgery, National University Hospital (CNHU-HKM), School of Medicine, University
刊名: Journal of Cancer Research and Treatment, 2018, Vol.6 (3), pp.60-69
来源数据库: Science and Education Publishing
DOI: 10.12691/jcrt-6-3-1
原始语种摘要: Background: Breast cancer treatment is challenging due to the inconsistence in tumour biomarker expression including progesterone receptor (PR), estrogen receptor-α (ERα) and GATA3 transcription factor. GATA3 has role in epithelial cell differentiation along with nuclear envelope protein lamin A. The breast cancer cell line MCF7 expresses ERα, abnormal GATA3 isoforms, low PR but lacks lamin A. MCF7 cells are resistant to tamoxifen targeting ERα and more anticancer drugs are being studied to kill them. One of the mechanisms surrounding breast cancer initiation is histone deacetylation. Our objective is to investigate the effect of histone deacetylase inhibitor (HDACI) on PR, ERα and GATA3 expression along with the induction of apoptosis in MCF7 cells forced expressing lamin A....
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关键词翻译
关键词翻译
  • breast 胸部
  • cancer 癌症
  • lamin 核纤层蛋白
  • tamoxifen 他莫西芬
  • ductal 管的
  • targeted 对准目标的
  • targeting 导向目标
  • Cancer 巨蟹座
  • estrogen 雌激素
  • histone 组蛋白