Beneficial effects of baicalein on a model of allergic rhinitis
作者: Tao LiuJing XuYungang WuXiaoxia LiDetao DingDengdian MaMengwei YaoWenzhong WeiWei ZhangShaohua WangJing YaoXiaoyu Li
作者单位: 1School of Clinical Medicine , Jining Medical University , Jining , Shandong, China
2 Affiliated Hospital of Jining Medical University , Jining , Shandong, China
3 School of Basic Medicine , Jining Medical University , Jining , Shandong, China
4 People’s Hospital of Hengshui , Hengshui Hebei, China
刊名: Acta Pharmaceutica, 2020, Vol.70 (1), pp.35-47
来源数据库: De Gruyter Journal
DOI: 10.2478/acph-2020-0009
关键词: BaicaleinOvalbuminAllergic rhinitisInflammatory factorsP-STAT3
原始语种摘要: Abstract Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in...
全文获取路径: De Gruyter 

  • baicalein 贝加因
  • rhinitis 鼻炎
  • allergic 变应性的
  • inflammation 炎症
  • nasal 鼻的
  • STAT 静止的
  • ovalbumin 卵白蛋白
  • sensitized 敏化的
  • lymphocyte 淋巴细胞
  • therapeutic 治疗的