Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin
作者: Namfa SermkaewThipapun Plyduang
作者单位: 1School of Pharmacy , Walailak University , Nakhon Si Thammarat , 80161, Thailand
2 Drug and Cosmetics Excellence Center , Walailak University , Nakhon Si Thammarat 80161, Thailand
刊名: Acta Pharmaceutica, 2020, Vol.70 (1), pp.77-88
来源数据库: De Gruyter Journal
DOI: 10.2478/acph-2020-0012
关键词: Moringa oleiferaSelf-microemulsifyingCrude extractKaempferolQuercetin
原始语种摘要: Abstract The aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera , a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera , were chosen as markers for quantification. The optimized formulation of SMEDDS consisted of propylene glycol dicaprylocaprate, polysorbate 80, and polyethylene glycol 400 (PEG 400) in a percentage ratio of 20:60:20 ( m / m ). SMEDDS emulsified immediately (within 20 s) after dilution in water, resulting in transparent microemulsions with a droplet size of 49 nm. SMEDDS could increase the solubility of kaempferol and quercetin to nearly 100 % within 15 min, whereas only a 30 % improvement in solubility was achieved in the case of crude...
全文获取路径: De Gruyter  (合作)

  • kaempferol 7三羟黄酮醇
  • extract 提取
  • quercetin 槲皮苷
  • dissolution 溶解
  • polysorbate 聚山梨酸酯
  • herbal 草本的
  • flavonoids 黄酮类似物
  • solubility 溶度
  • medicinal 医学的
  • transparent 透媚