Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets
作者: Marilena VlachouEfthymia GeraniouAngeliki Siamidi
作者单位: 1Section of Pharmaceutical Technology, Department of Pharmacy , School of Health Sciences , National and Kapodistrian University of Athens
刊名: Acta Pharmaceutica, 2020, Vol.70 (1), pp.49-61
来源数据库: De Gruyter Journal
DOI: 10.2478/acph-2020-0010
关键词: Matrix tabletsCompression coated tabletsFurosemideEudragit®Poly(ethylene oxide)Polyvinylpyrrolidone
原始语种摘要: Abstract Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. The results indicate that the use of Eudragit® in conjunction with either PVP or lactose monohydrate led to a slower release rate in the intestinal fluids compared to Lasix®....
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关键词翻译
关键词翻译
  • tablets 平片体
  • ethylene oxide 氧丙环
  • furosemide 呋喃苯胺酸
  • release 释放
  • coated 涂渍的
  • monohydrate 一水化物
  • compression 压缩
  • minimization 最小化
  • matrices 基体
  • preparing 预梳