Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid
作者: David Calderón GuzmánNorma Osnaya BrizuelaMaribel Ortíz HerreraErnestina Hernández GarcíaGerardo Barragán MejíaHugo Juárez OlguínArmando Valenzuela PerazaJonas AttilusNorma Labra Ruíz
作者单位: 11Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) México City, México
22Laboratorio de Bacteriología Experimental INP, México City, México
33Laboratorio de Farmacología, INP México City, México
刊名: Acta Pharmaceutica, 2016, Vol.66 (3), pp.443-448
来源数据库: De Gruyter Journal
DOI: 10.1515/acph-2016-0027
关键词: cerebrolysindopamine3-nitropropionic acidoxidative stress
原始语种摘要: Abstract The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group,...
全文获取路径: De Gruyter 
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关键词翻译
关键词翻译
  • administration 管理
  • hypothesis 假说
  • oxidative 氧化的
  • dopaminergic 多巴胺能的多巴胺能的
  • stress 应力
  • increased 增加
  • brains 智力
  • cortex 皮层
  • calcium 
  • GSH 谷胱甘肽