Branched PLGA derivatives with tailored drug delivery properties
作者: Eva SnejdrovaStepan PodzimekJuraj MartiskaOndrej HolasMilan Dittrich
作者单位: 1Charles University , Faculty of Pharmacy , 500 05 Hradec Kralove Czech Republic
2 SYNPO , 532 07 Pardubice , Czech Republic
3 Wyatt Technology Europe , 56307 Dernbach , Germany
4 Institute of Chemistry and Technology of Macromolecular Materials , University of Pardubice , 532 10 Pardubice , Czech Republic
刊名: Acta Pharmaceutica, 2020, Vol.70 (1), pp.63-75
来源数据库: De Gruyter Journal
DOI: 10.2478/acph-2020-0011
关键词: PLGABranchingStar polymerPolymer synthesisLight scattering
原始语种摘要: Abstract Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic -co- glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic -co- glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, in situ forming implants or nanoparticles. A series of poly(lactic -co- glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation...
全文获取路径: De Gruyter  (合作)

  • tailored 简明的
  • lactic 乳汁的
  • derivatives 派生物
  • biodegradable 生物降解的
  • properties 道具
  • delivery 移交
  • block 滑车
  • synthesis 合成
  • branched 分枝的
  • hydrophobicity 疏水性