作者: Rumena PetkovaPavlina ChelenkovaHusein YemendzhievIliya TsekovStoyan ChakarovZlatko Kalvatchev
作者单位: 1Scientific Technological Service (STS), Sofia, Bulgaria
2Scientific Technological Service (STS Ltd.), Sofia, Bulgaria
3Burgas University ‘Prof. Dr. Asen Zlatarov’, Burgas, Bulgaria
4Molecular Virology Laboratory, Military Medical Academy, Sofia, Bulgaria
5Sofia University “St. Kliment Ohridsky”, Sofia, Bulgaria
刊名: Biotechnology & Biotechnological Equipment, 2013, Vol.27 (6), pp.4217-4221
来源数据库: Diagnosis Press Journal
DOI: 10.5504/BBEQ.2013.0104
关键词: HPV DNACINcarcinogenesisp53P72R
原始语种摘要: HPV infection is a major pathogenetic factor in cervical carcinoma as well as in many of the squamous cancers of head and neck and other epithelial cancers. Persistence of HPV DNA detectable by routine methods is considered to be a risk factor for advanced CIN and, in patients treated by surgery or non-surgical treatment modalities (radiotherapy, chemotherapy), HPV persistence is believed to be associated with increased risk for local recurrence. In terms of survival, however, it has been repeatedly proven that patients with cervical cancer and other HPV-associated cancers with detectable HPV DNA tend to have better outcomes than patients with HPV-negative tumours. The P72R polymorphism in the human TP53 gene has been contemplated as an independent phenotype modifier in cancers,...
全文获取路径: Diagnosis Press  (合作)
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关键词翻译
关键词翻译
  • transformation 变换
  • cervical 颈的
  • repeatedly 重复地
  • detectable 可探测的
  • mutagenesis 突变形成
  • demonstrated 探明的储量
  • further 进一步
  • independent 独立的
  • increased 增加
  • however 然而