Muscle side population cells from dystrophic or injured muscle adopt a fibro-adipogenic fate.
作者: Christopher M PentonJennifer M Thomas-AhnerEric K JohnsonCynthia McAllisterFederica Montanaro
刊名: PLoS ONE, 2017, Vol.8 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0054553
原始语种摘要: Muscle side population (SP) cells are rare multipotent stem cells that can participate in myogenesis and muscle regeneration upon transplantation. While they have been primarily studied for the development of cell-based therapies for Duchenne muscular dystrophy, little is known regarding their non-muscle lineage choices or whether the dystrophic muscle environment affects their ability to repair muscle. Unfortunately, the study of muscle SP cells has been challenged by their low abundance and the absence of specific SP cell markers. To address these issues, we developed culture conditions for the propagation and spontaneous multi-lineage differentiation of muscle SP cells. Using this approach, we show that SP cells from wild type muscle robustly differentiate into satellite cells and form...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • muscle 肌肉
  • adipogenic 生脂的
  • cells 麻风细胞
  • dystrophic 似营病养不良
  • lineage 血统
  • myogenic 肌原性的
  • myogenesis 肌生成
  • differentiate 微分
  • dystrophy 营养障碍
  • mesenchymal 间叶细胞的