Retinal glia promote dorsal root ganglion axon regeneration.
作者: Barbara LorberDaniel J ChewStefanie M HauckRachel S ChongJames W FawcettKeith R Martin
刊名: PLoS ONE, 2017, Vol.10 (3)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0115996
原始语种摘要: Axon regeneration in the adult central nervous system (CNS) is limited by several factors including a lack of neurotrophic support. Recent studies have shown that glia from the adult rat CNS, specifically retinal astrocytes and Müller glia, can promote regeneration of retinal ganglion cell axons. In the present study we investigated whether retinal glia also exert a growth promoting effect outside the visual system. We found that retinal glial conditioned medium significantly enhanced neurite growth and branching of adult rat dorsal root ganglion neurons (DRG) in culture. Furthermore, transplantation of retinal glia significantly enhanced regeneration of DRG axons past the dorsal root entry zone after root crush in adult rats. To identify the factors that mediate the growth promoting...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • regeneration 再生
  • ganglion 脑神经节
  • retinal 视黄醛
  • promote 助长
  • adult 成体
  • dorsal 背面的
  • conditioned 经过调节的
  • glial 神经胶质的
  • neurite 轴索轴突
  • neurotrophic 神经营养的