How cell number and cellular properties of blood-banked red blood cells of different cell ages decline during storage.
作者: Wei-Wei TuoDi WangWen-Jing LiangYao-Xiong Huang
刊名: PLoS ONE, 2017, Vol.9 (8)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0105692
原始语种摘要: AIMS: Numerous studies have suggested that transfusion of red blood cells (RBCs) stored over a long period of time may induce harmful effects due to storage-induced lesions. However, the underlying mechanisms responsible for this damage have not been identified. Furthermore, it is unclear why and how up to 30% of long-stored RBCs disappear from the circulation within 24 hours after transfusion. The aim of this study was to determine how the cell number of RBCs of different ages changes during storage and how these cells undergo cumulative structural and functional changes with storage time. METHODS AND RESULTS: We used Percoll centrifugation to fractionate the RBCs in blood bank stored RBC units into different aged sub-populations and then measured the number of intact cells in each...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • cells 麻风细胞
  • stored 贮藏了的
  • number 号码
  • storage 蓄水量
  • blood 血液
  • properties 道具
  • fraction 分数
  • harmful 有害的
  • units 部件
  • functional 功能的