21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF-κB-Dependent Manner
作者: Woo Seok YangJaeyoung KoEunji KimJi Hye KimJae Gwang ParkNak Yoon SungHan Gyung KimSungjae YangHo Sik RhoYong Deog HongSong Seok ShinJae Youl Cho
作者单位: 1epartment of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
2Medical Beauty Research Institute, AmorePacific R&D Center, Yongin 446-729, Republic of Korea
3Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
4Department of Genetic Engineering, Sun
刊名: Mediators of Inflammation, 2014, Vol.2014
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2014/658351
原始语种摘要: 21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree Camellia sinensis (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ATS-E3. In this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ATS-E3 in macrophage-mediated inflammatory responses. ATS-E3 remarkably diminished cellular responses of macrophages such as FITC-dextran-induced phagocytic uptake, sodium nitroprusside- (SNP-) induced radical generation, and LPS-induced nitric oxide (NO) production. Analysis of its molecular...
全文获取路径: DOAJ  (合作)
影响因子:3.882 (2012)

  • induced 感应的
  • triterpenoid 三萜系化合物
  • beneficial 有利
  • inflammatory 激怒的
  • inhibitory 禁止的
  • nitroprusside 硝普盐
  • ATS Acoustic Transmission System
  • antidiabetic 治糖尿[病]药
  • phagocytic 吞噬细胞的
  • translocation 移位