Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin.
作者: Janice K V TamKwan-Wa LauLeo T O LeeJessica Y S ChuKwong-Man NgAlain FournierHubert VaudryBilly K C Chow
刊名: PLoS ONE, 2017, Vol.6 (4)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0019384
原始语种摘要: At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear. In addition, the elusive similarities of secretin and orexin in terms of both structures and functions suggest a common ancestral origin early in the vertebrate lineage. In this article, with the cloning and functional characterization of secretin receptors from lungfish and X. laevis as well as frog (X. laevis and Rana rugulosa) secretins, we provide evidence that the secretin ligand-receptor pair has already diverged and become highly specific by the emergence of tetrapods. The secretin receptor-like sequence cloned from lungfish indicates that the secretin receptor was descended from a VPAC-like receptor prior the advent of...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • 不清楚的 总科
  • secretin 肠促胰液素
  • receptor 接受体
  • found 创立
  • tetrapoda 四足类
  • evidence 
  • vertebrate 有脊椎的
  • lungfish 肺鱼目
  • demonstrated 探明的储量
  • superfamily 总科
  • unclear 总科