The use of urinary proteomics in the assessment of suitability of mouse models for ageing.
作者: Esther Nkuipou-KenfackJoost P SchanstraSeerat BajwaMartin PejchinovskiClaire VinelCédric DrayPhilippe ValetJean-Loup BascandsAntonia VlahouThomas KoeckMelanie BorriesHauke BuschWibke Bechtel-WalzTobias B HuberKarl L RudolphAndreas PichHarald MischakPetra Zürbig
刊名: PLoS ONE, 2017, Vol.12 (2)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0166875
原始语种摘要: Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they have a shorter lifespan in comparison to humans and are also genetically close to humans. To assess the translatability of mouse ageing to human ageing, the urinary proteome in 89 wild-type (C57BL/6) mice aged between 8-96 weeks was investigated using capillary electrophoresis coupled to mass spectrometry (CE-MS). Using age as a continuous variable, 295 peptides significantly correlated with age in...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • mouse 小鼠
  • ageing 老化
  • urinary 尿的
  • related 有关的
  • observed 观察到的
  • increased 增加
  • classifier 分级机
  • several 各自
  • investigate 
  • homology 同源